Cannabis for Arthritis

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Spray Study

A study by GW Pharmaceuticals shows benefits in treatment of arthritis.  The study included 58 RA patients. They had no history of psychiatric disorders, substance misuse, epilepsy, or severe heart, kidney, or liver problems.

First, patients rated their pain at rest, during movement, and first thing in the morning. They also rated their quality of sleep.

Next, the patients were given one of two sprays to use every evening for about a month. Sativex was one of those sprays. The other was an empty spray (placebo).

Sativex was given to 31 patients. The other 27 patients got the placebo. No one knew which patients had gotten Sativex.

Sativex contains THC (delta-9-tetrahydrocannabinol) and CBD (cannabidiol). Those are key therapeutic compounds in cannabis that have been shown by other studies to produce effects on pain and inflammation, write the researchers.

They included rheumatologist David R. Blake of the Royal National Hospital forRheumatic Diseases in Bath, England.

Study’s Results

Compared with the placebo group, patients taking Sativex had notable improvements in pain (including pain during movement and pain at rest), sleep quality, and RA disease activity, the researchers report.

Morning pain didn’t change much but was “surprisingly low” to begin with, write Blake and colleagues.

The sprays were only used in the evening to minimize any intoxication. The most common side effects with Sativex were dizziness (eight patients, or 26% of the Sativex group), dry mouth (four patients, or 13%), and lightheadedness (three patients, or 10% of those taking Sativex).

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ARTHRITIS

Cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
http://www.pnas.org/cgi/content/full/97/17/9561

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conten…00013/art00008

Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals.o…stract/45/1/50

Suppression of fibroblast metalloproteinases by ajulemic acid,
http://www.ncbi.nlm.nih.gov/pubmed/16927387

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
http://www.unboundmedicine.com/medli…inoid_receptor

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat
http://www.unboundmedicine.com/medli…_arthritic_rat

Cannabis based medicine eases pain and suppresses disease
http://www.medicalnewstoday.com/articles/33376.php

Pot-Based Drug Promising for Arthritis
http://www.webmd.com/rheumatoid-arth…-for-arthritis

Anti-inflammatory compound from cannabis found in herbs
http://www.rsc.org/chemistryworld/Ne…e/24060801.asp

ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L.
http://www.ukcia.org/research/Analge…stituents.html

US Patent 6132762 – Transcutaneous application of marijuana

Cannabis May Suppress Immune System
http://lupus.webmd.com/news/20030415…-immune-system

 

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